Phospholipases

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Published by London, Academic Press in San Diego, Calif .

Written in English

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Edition Notes

Book details

Statementedited by Edward A. Dennis.
SeriesMethods in enzymology -- v.197
ContributionsDennis, Edward A.
The Physical Object
Pagination590p.
Number of Pages590
ID Numbers
Open LibraryOL22233895M
ISBN 10012182098X

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In Lipases and Phospholipases: Methods and Protocols, expert researchers in the field provide key techniques to investigate these essential enzymes. Focusing on fundamental issues, current and new applications as well as practical step-by-step protocols, and the extensive applications of lipases and the potential application of phospholipases.

In Lipases and Phospholipases: Methods and Protocols, expert researchers in the field provide key techniques to investigate these essential enzymes. Focusing on fundamental issues, current and new applications as well as practical step-by-step protocols, and the extensive applications of lipases and the potential application of phospholipases Format: Hardcover.

This book explores current and new applications to explore the applications of lipases and phospholipases, including activity screening and expression, optimization of the biocatalyst production and performances, and applications of lipases, phospholipases, and esterases.

The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases Format: Hardcover.

Richard W. Titball, Ajit K. Basak, in The Comprehensive Sourcebook of Bacterial Protein Toxins (Third Edition), INTRODUCTION. Phospholipases have a special place in the history of bacterial toxinology because the α-toxin (phospholipase C) of Clostridium perfringens was the first bacterial toxin shown to have an enzymatic mode of action.

This certainly explained the remarkable Phospholipases book of. Get this from a library. Phospholipases. [Edward A Dennis;] ISBN: X OCLC Number: Description: 1 v. (XXXIV p.): illustrations.

Phospholipases are Phospholipases book bioactive venom component and have been implicated in allergic reactions to insect bites, for example, from the fire ant (Hoffman et al., ) (known as Sol I 1), and stings, as from Phospholipases book honeybee (Sobotka et al., ) (known as Api m 1).

It is regarded as a major allergen due to preponderance of IgE to phospholipase in. Get this from a library. Phospholipases. [Edward A Dennis;] ISBN: X OCLC Number: Description: XXXIV, Seiten: Illustrationen.

Phospholipases A2 (PLA2s) EC are enzymes that cleave fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glycerol molecule.

This particular phospholipase specifically recognizes the sn-2 acyl bond of phospholipids and catalytically hydrolyzes the bond, Phospholipases book arachidonic acid and lysophosphatidic : BRENDA entry. Phospholipases: An Overview: Methods and Protocols Chapter (PDF Available) in Methods in molecular biology (Clifton, N.J.) August with Reads How we measure 'reads'.

Authoritative and accessible, Lipases and Phospholipases: Phospholipases book and Protocols, Second Edition serves as an updated reference book for the large scientific community, both seasoned and novice, working with lipases, phospholipases, and related enzymes.

Keywords. Phagocytosis, the process by which particulate matter is taken up by cells, is characteristic of many cell types including the pigmented epithelium of the eye, Langerhans cells in the skin, the microglia in the brain, and Kupffer cells in the liver.

Of particular interest clinically are the “professional” phagocytes: neutrophils, monocytes, and tissue macrophages. Their ability to Cited by: 1.

Purchase Phospholipases, Volume - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1. Phospholipases play central roles in regulating signalling during numerous cellular events including proliferation, G protein-coupled receptor signalling and neuronal activation by catalysing the lysis of phosphorylated lipids.

In turn, second messengers are released, which control downstream events. About this book. Lipases and Phospholipases are key control elements in mammalian metabolism. They share many common features that set them apart from other metabolic enzyme classes, most importantly their association with biological membranes.

Their potential as drug targets for the treatment of metabolic diseases is widely recognized, and the. The Paperback of the The Phospholipases by Moseley Waite at Barnes & Noble. FREE Shipping on $35 or more. Due to COVID, orders may be delayed.

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The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function.

Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases Brand: Springer New York.

Glycerophospholipids in Brain: Phospholipases A 2 in Neurological Disorders Akhlaq A. Farooqui and Lloyd A. Horrocks. Glycerophospholipids in Brain: Phospholipases A 2 in Neurological Disorders provides a synthesis of material on the metabolism of phospholipids in the brain which has previously only been available in a scattered number of original papers and reviews.

J Biochem. Mar;(3) Phospholipase A2. Murakami M(1), Kudo I. Author information: (1)Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Hatanodai, Shinagawa-ku, TokyoJapan. Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of.

Phospholipases and a great selection of related books, art and collectibles available now at   Phospholipases in Plant Signaling. Signaling and Communication in Plants (Book 20) Thanks for Sharing. You submitted the following rating and review. We'll publish them on our site once we've reviewed : Springer Berlin Heidelberg.

Open Library is an open, editable library catalog, building towards a web page for every book ever published.

Phospholipases in Health and Disease by Paramjit S. Tappia, Naranjan S. Dhalla,Springer edition, hardcover. Define phospholipase. phospholipase synonyms, phospholipase pronunciation, phospholipase translation, English dictionary definition of phospholipase.

Any of several enzymes that hydrolyze specific ester bonds in phospholipids. n chem an enzyme. Phospholipase definition is - any of several enzymes that hydrolyze lecithins or phosphatidylethanolamines —called also lecithinase.

Phospholipase A 2 is one of the most intensively studied membrane proteins which hydrolyzes phospholipids at the sn-2 position to form fatty acid and lysophospholipid products.

These are small proteins and the 3-D structures are known to high resolution for several species. Phospholipase A 2 proteins are of high pharmaceutical concern since they are responsible for the release of arachidonic. Free 2-day shipping. Buy Methods in Molecular Biology: Lipases and Phospholipases: Methods and Protocols (Hardcover) at nd: Georgina Sandoval.

Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders Akhlaq A. Farooqui and Lloyd A. Horrocks Glycerophospholipids in Brain: Phospholipases A2 in Neurological Disorders provides a synthesis of material on the metabolism of phospholipids in the brain which has previously only been available in a scattered number of original papers and reviews.

Buy Phospholipases in Plant Signaling Hardback by ISBN: No products in the cart. Phospholipase A2 (PLA2) designates a class of enzymes that hydrolyze the sn-2 ester of glycerophospholipids to produce a fatty acid and a lysophospholipid. It has become clear that some of these enzymes liberate arachidonic acid in mammalian cells for the biosynthesis of eicosanoids, and thus there has been considerable interest in developing PLA2 inhibitors.

Phospholipases Act on Membrane/Micellar Phospholipid Substrates. Phospholipases are major digestive enzymes and play a critical role in most physiological processes including the generation of numerous signaling lipids, and in aggregate, seem to affect all diseases in some manner.

Phospholipase: An enzyme that catalyzes the splitting of a phospholipid molecule by the addition of water. Also called a lecithinase. There are a number of phospholipases. They are grouped on the basis of the specific chemical bond they split. Lipases and Phospholipases are key control elements in mammalian metabolism.

They share many common features that set them apart from other metabolic enzyme classes, most importantly their association with biological membranes. Their potential as drug targets for the treatment of metabolic diseases is widely recognized, and the first lipase inhibitor drugs have been successfully introduced.

phospholipase B: 1. Synonym(s): lysophospholipase 2. a mixture of phospholipase A 1 and phospholipase A 2. The second group comprises the phospholipases, which, on the basis of the bond on which they act, are further subdivided into phospholipases A 1 (EC 3.

26 Lecitase Ultra is a phospholipase A 1. Phospholipases are widely distributed in nature and are found in almost all mammalian cells. In mammals, the principal substrates of PLA 1, PLA 2, and PLD are phosphatidylcholine and phosphatidylethanolamine, whereas PLC acts on phosphatidylinositol (PI) and its mono- and bis-phosphates (PIP and PIP 2).

phospholipase [fos″fo-lip´ās] any of four enzymes (phospholipase A to D) that catalyze the hydrolysis of a phospholipid. phospholipase (fos'fō-lip'ās), An enzyme that catalyzes the hydrolysis of a phospholipid. Synonym(s): lecithinase phospholipase (fŏs′fō-lĭp′ās′, -lī′pās′) n.

Interaction of phospholipases with interfaces The catalytic turnover of phospholipases at the interface distinguishes them from the general class of esterases (Fig. Therefore, the study of phospholipases must include an understanding of their interaction with the lipid interface.

The increased enzyme. Phospholipases are a group of esterases that are composed of two major categories, the acyl hydrolases and the phosphodiesterases.

Investigations on the phospholipases of Aspergillus species have been very limited to date. Indirect evidence for extracellular phospholipase activity was demonstrated in Aspergillus fumigatus by identifying the accumulation of phospholipid breakdown products in Cited by: 3.

"Proceedings of a NATO Advanced Research Workshop on Esterases, Lipases, and Phospholipases, held September, in Bordeaux, France"--T.p. verso. Includes bibliographical references and index. ISBN. Identifying numbers.

LCCN: OCLC: The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest.

The key role is played by phospholipases from the A 2 superfamily: enzymes which are involved in inflammation through participation in pro- and anti-inflammatory Cited by:.

Find many great new & used options and get the best deals for Nato Science Series A: Esterases, Lipases, and Phospholipases Vol. From Structure to Clinical Significance (, Hardcover) at the best online prices at eBay!

Free shipping for many products!Phospholipase A2 represents a class of heat-stable, calcium-dependent enzymes catalyzing the hydrolysis of the 2-acyl bond of 3-n-phosphoglycerides. This enzyme is named Phospholipase A2 to denote its 2-acyl specificity (Uthe ). Phospholipase A2 has been isolated from pancreas, snake and bee venoms.

Forst et al. (), Chan et al.Legionella pneumophila possesses several virulence mediating factors; for example, it has two protein export systems: the type II (Lsp) and the type IVB (Dot/Icm) secretion systems. Both systems transport effector molecules, including lipolytic proteins such as phospholipases.

L. pneumophila possesses two major phospholipase activities, phospholipase A (PLA) and lysophospholipase A (LPLA Cited by: 1.

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